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Technique for Intranasal Administration of α-Synuclein Aggregates
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Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy

Johannes Brettschneider1, EunRan Suh2, John L Robinson1

  • 1Center for Neurodegenerative Disease Research (CNDR), University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.

Journal of Neuropathology and Experimental Neurology
|September 12, 2018
PubMed
Summary

Alpha-synuclein (α-syn) pathology in multiple system atrophy (MSA) evolves over time, starting in distinct brain regions for striato-nigral degeneration (SND) and olivo-ponto-cerebellar atrophy (OPCA) and converging as the disease progresses. A specific GBA variant is linked to MSA.

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