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Updated: Feb 5, 2026

Functionalization and Dispersion of Carbon Nanomaterials Using an Environmentally Friendly Ultrasonicated Ozonolysis Process
Published on: May 30, 2017
Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures
Jancineide Oliveira de Carvalho1,2,3, Francilio de Carvalho Oliveira1,2, Sérgio Antonio Pereira Freitas2
1Instituto de Ciência e Tecnologia, Universidade Brasil, Rua Carolina da Fonseca, 584, Bairro Itaquera, São Paulo, 08230-030, Brazil.
Purpose Of Review:
To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs).
Recent Findings:
The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity. Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.
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