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Optocardiography and Electrophysiology Studies of Ex Vivo Langendorff-perfused Hearts
Published on: November 7, 2019
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Leadless multisite pacing: A feasibility study using wireless power transfer based on Langendorff rodent heart
Hongming Lyu1, Mathews John2, David Burkland2,3
1Department of Electrical and Computer Engineering, University of California Los Angeles, Los Angeles, California.
Journal of Cardiovascular Electrophysiology
|September 12, 2018
Summary
Wireless power transfer enables multisite cardiac pacing, overcoming limitations of current leadless pacemakers. This technology offers a feasible approach for future cardiac resynchronization therapy (CRT) systems.
Area of Science:
- Biomedical Engineering
- Cardiovascular Technology
- Implantable Devices
Background:
- Ventricular dyssynchrony affects 15-30% of patients with impaired cardiac function, necessitating cardiac resynchronization therapy (CRT).
- Current leadless pacemakers are limited to single-chamber pacing, despite the need for multisite pacing in CRT.
Purpose of the Study:
- To demonstrate the feasibility of multisite, simultaneous cardiac pacing using miniaturized nodes powered by wireless power transfer (WPT).
Main Methods:
- Developed a wireless energy transfer system using resonant coupling at ~200 MHz to power multiple pacing nodes.
- Validated the system ex vivo on Langendorff rodent heart models, pacing two hearts simultaneously up to 30 cm apart.
Main Results:
- Successfully paced ex vivo heart models using pacing nodes powered wirelessly at distances of 2-3 cm with 0.3 W.
- Demonstrated reliable simultaneous pacing of two heart models 30 cm apart using 5 W output power.
Conclusions:
- Wireless power transfer is a viable technology for achieving multisite, wireless cardiac pacing.
- This study provides a conceptual framework for future iterations of WPT-based CRT systems with potential clinical utility.
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