Other Helicobacters and the gastric microbiome

Area of Science:

• Microbiology
• Gastroenterology
• Human Microbiome

Background:

• The gastric microbiome and non-Helicobacter pylori-Helicobacter (NHPH) infections are areas of active research.
• Understanding these areas is crucial for diagnosing and treating various gastrointestinal conditions.

Purpose of the Study:

• To review the most relevant literature published between April 2017 and March 2018 on NHPH infections and the human gastric microbiome.
• To synthesize recent findings on novel NHPH species, diagnostic methods, pathogenesis, prevalence, and prevention.
• To summarize new insights into the structure and function of the gastric microbiome, including the impact of H. pylori infection and proton-pump inhibitor usage.

Main Methods:

• Literature review of scientific articles published from April 2017 to March 2018.
• Focus on studies related to NHPH infections in humans and animals.
• Emphasis on research concerning the human gastric microbiome, its structure, and influencing factors.

Main Results:

• Identification of novel NHPH species and improved diagnostic methods.
• Enhanced understanding of NHPH infection pathogenesis through cell line and animal model studies.
• New data on NHPH prevalence and potential prevention strategies.
• Detailed information on gastric microbiota structure during H. pylori infection and across geographical locations.
• Studies on the impact of proton-pump inhibitor usage on the gastric microbiome.
• Introduction of RNA-based sequencing for assessing the active gastric microbiome and its functional capabilities.

Conclusions:

• Recent research has significantly advanced the understanding of NHPH infections and the human gastric microbiome.
• Novel diagnostic and therapeutic strategies for NHPH infections are emerging.
• The functional capacity of the gastric microbiome is being elucidated through advanced sequencing techniques.