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Cognitive deficits and psychopathological symptoms among children with medulloblastoma

Annamária Szentes1, Nikoletta Erős1, Zoltán Kekecs2

  • 12nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.

European Journal of Cancer Care
|September 12, 2018
PubMed

Insights

Children surviving medulloblastoma (MB) often experience cognitive deficits and psychopathological symptoms. These impairments, including lower IQ and increased anxiety disorders, can occur independently, impacting long-term quality of life.

Area of Science:

  • Neuroscience
  • Pediatric Oncology
  • Psychiatry

Background:

  • Children with medulloblastoma (MB) are at high risk for cognitive sequelae.
  • Understanding these deficits and associated psychopathological symptoms is crucial for survivors.

Purpose of the Study:

  • To investigate cognitive deficits and psychopathological symptoms in medulloblastoma survivors.
  • To analyze the relationship between cognitive impairments and psychological conditions in this population.

Main Methods:

  • Administered the Wechsler Intelligence Scale for Children and the Mini International Neuropsychiatric Interview (MINI-KID) to 34 MB survivors.
  • Compared MB survivors' cognitive functioning and psychopathological symptom prevalence with control groups.

Main Results:

  • MB survivors exhibited lower global IQ and impaired functioning across all IQ subscales, particularly processing speed.
  • Higher radiation dose and high-dose chemotherapy with stem cell rescue were linked to lower global IQ.
  • Prevalence of compulsive disorder, generalized anxiety, separation anxiety, and PTSD was significantly higher in MB survivors.
  • No significant correlation was found between cognitive deficits and psychopathological symptoms.

Conclusions:

  • Medulloblastoma survivors face significant cognitive and psychopathological impairments.
  • These cognitive and psychological issues may develop independently in medulloblastoma survivors.
  • Further research is needed to understand the independent trajectories of these impairments.

Keywords:
IQcognitive outcomeslate effectsmedulloblastomapaediatric brain tumourpsychopathological symptoms

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