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Serum HMGB1 levels and its association with endothelial dysfunction in patients with polycystic ovary syndrome

Hao-Hua Wang1, Min Lin, Guang-da Xiang

  • 1Department of Endocrinology, Tungwah Hospital of Sun Yat-Sen University, Dongguan, China. hello_vanwang@sohu.com.

Physiological Research
|September 12, 2018
PubMed

Insights

High-mobility group box 1 (HMGB1) is elevated in polycystic ovary syndrome (PCOS) and linked to endothelial dysfunction. Metformin treatment reduced HMGB1 levels, suggesting HMGB1

Area of Science:

  • Endocrinology
  • Cardiovascular Research
  • Inflammation Biology

Background:

  • High-mobility group box 1 (HMGB1) is implicated in systemic inflammation and atherosclerosis.
  • Polycystic ovary syndrome (PCOS) is associated with increased cardiovascular risk and endothelial dysfunction.

Purpose of the Study:

  • To investigate the relationship between serum HMGB1 levels and endothelial function in women with PCOS.
  • To assess the effect of metformin on serum HMGB1 levels and endothelial function in PCOS patients.

Main Methods:

  • Serum HMGB1 levels were measured using ELISA in 80 PCOS patients and 80 controls.
  • Endothelial function was assessed via high-resolution ultrasound measuring flow-mediated dilation (FMD).
  • PCOS patients received metformin (1,500 mg/day) for 3 months.

Main Results:

  • Serum HMGB1 levels were significantly higher in PCOS patients compared to controls (24.87 vs. 8.82 ng/ml).
  • Metformin treatment significantly reduced HMGB1 levels in PCOS patients.
  • Higher HMGB1 levels correlated with increased testosterone and decreased FMD in PCOS patients.

Conclusions:

  • Serum HMGB1 levels are elevated and correlated with endothelial dysfunction in PCOS.
  • HMGB1 may play a role in the early stages of atherosclerosis in PCOS.
  • Metformin therapy may improve endothelial function by reducing HMGB1 levels in PCOS.

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