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Tandospirone-Induced Rhabdomyolysis
Kensuke Miyazaki, Masabumi Otaka1, Norio Yasui-Furukori2
1Department of Pediatrics, Aomori Rosai Hospital, Hachinohe, Japan.
Clinical Neuropharmacology
|September 12, 2018
Summary
High doses of tandospirone, a 5-HT1A receptor agonist, can cause rhabdomyolysis in adolescents. This case highlights the risks of excessive psychotropic medication in vulnerable young patients.
Area of Science:
- Neuroscience
- Pharmacology
- Toxicology
Background:
- Rhabdomyolysis is muscle cell breakdown causing pain and weakness.
- Psychotropic medications are known causes, but tandospirone has not been previously reported.
Observation:
- A 15-year-old girl with PTSD developed symptoms after a high dose of tandospirone (60mg daily) alongside valproic acid.
- She experienced appetite loss, muscle pain, weakness, and malaise.
- Creatine phosphokinase levels peaked at 35,530 IU/L.
Findings:
- Tandospirone-induced rhabdomyolysis is a potential adverse effect.
- Elevated muscle enzymes (CK, LDH) and liver enzymes (AST, ALT) were observed.
Implications:
- High-dose partial 5-HT1A receptor agonists may pose risks to adolescent patients with mental health conditions.
- Careful dosing and monitoring are crucial for at-risk populations.
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