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Effect of Vitamin D Deficiency on Hypertrophic Scarring
Bilsev Ince1, Ilker Uyar, Mehmet Dadaci2
1*All authors are affiliated with the Department of Plastic, Reconstructive and Aesthetic Surgery, Meram Faculty of Medicine, Necmettin Erbakan University, Konya, Turkey.
Insights
Vitamin D deficiency is linked to hypertrophic scarring (HS). Supplementing vitamin D and undergoing scar revision significantly reduced scar width in patients with low vitamin D levels.
Area of Science:
- Dermatology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D deficiency is associated with various diseases.
- No prior studies have investigated the link between vitamin D deficiency and hypertrophic scarring (HS).
Purpose of the Study:
- To explore the relationship between vitamin D deficiency and HS.
- To evaluate the impact of vitamin D replacement therapy on HS development.
Main Methods:
- Patients with HS were assessed for vitamin D levels.
- 50 patients with vitamin D levels < 25 ng/mL were divided into three groups: no treatment, vitamin D replacement only, and surgical excision with vitamin D replacement.
- Scar width was measured after at least one year post-trauma.
Main Results:
- A significant correlation was found between HS and vitamin D levels (p < .05).
- Group 3, receiving both vitamin D replacement and surgical excision, showed a statistically significant decrease in scar width (p < .05).
Conclusions:
- Vitamin D deficiency may play a role in hypertrophic scarring.
- Increasing vitamin D levels to above 25 ng/mL prior to scar revision may help reduce scar width.
Background:
Although many different diseases have been reported with vitamin D deficiency, the authors failed to find any studies on the association of hypertrophic scarring (HS) in the literature.
Objective:
The authors aimed to determine the relationship between vitamin D deficiency and HS and investigate the effect of replacement therapy on HS development in patients with vitamin D deficiency.
Patients And Methods:
Patients who presented to the authors' outpatient clinic with HS between 2013 and 2016 were included in the study. In the first stage, all the patients with HS complaints were assessed for vitamin D levels. In the second stage, 50 patients with a vitamin D level less than 25 ng/mL and a linear scar after at least 1 year of trauma were randomly divided into 3 groups. Group 1: patients who did not accept any medical or surgical treatment; Group 2: patients who were subjected to vitamin D replacement only; Group 3: patients who underwent surgical excision and suturation after vitamin D replacement.
Results:
A statistically significant correlation was found between HS and vitamin D levels (p < .05). A statistically significant decrease in scar width was observed in Group 3 (p < .05).
Conclusion:
Increasing vitamin D levels to above 25 ng/mL before scar revision and vitamin D deficiency in patients with HS may help reduce scar width.
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