Related Experiment Video
Updated: Feb 5, 2026
10:51
Frame-by-Frame Video Analysis of Idiosyncratic Reach-to-Grasp Movements in Humans
Published on: January 15, 2018
8.9K
The Influence of Side Effect Information Framing on Nocebo Effects
Kate Faasse1, Anna Huynh1, Sarah Pearson1
1School of Psychology, University of New South Wales, Sydney, Australia.
Summary
Positive framing of side effect information may temporarily reduce nocebo effects, but this benefit does not last. Nocebo effects can also spread to unrelated symptoms over time.
Area of Science:
- Psychology
- Medical Research
- Clinical Trials
Background:
- Nocebo effects, or negative health outcomes from negative expectations, are influenced by information about potential side effects.
- Balancing the disclosure of side effect information is crucial, as both over- and under-disclosure can be problematic.
Purpose of the Study:
- To investigate if positively framed information about side effects (emphasizing low likelihood) can mitigate nocebo effects compared to negatively framed information (emphasizing high likelihood).
Main Methods:
- 112 participants received sham capsules and were randomized into positive framing, negative framing, or no-treatment control groups.
- Side effect expectations were measured post-information, and actual symptoms (framed and unframed) were assessed during the session and at 24-hour follow-up.
Main Results:
- Nocebo effects were observed for framed side effects and, at follow-up, for other unmentioned symptoms.
- Positive framing initially reduced side effect symptoms compared to negative framing, but this effect diminished by the 24-hour follow-up.
- Participant expectations regarding side effects did not significantly differ between positive and negative framing conditions.
Conclusions:
- While positive framing offers short-term relief from side effects, its long-term efficacy in reducing nocebo effects is limited.
- Nocebo effects demonstrated a tendency to generalize to unmentioned symptoms within 24 hours.
- Further research is required to explore strategies for sustaining the positive impact of framing over extended periods.
Related Concept Videos
03:26Framing Effects
8.0K
Information is everywhere and its presentation—such as how and when items are presented—can impact our perceptions and decisions surrounding the info. This broad concept umbrellas framing effects—influences that occur due to the way information is framed in its appearance, whether it’s purely the order or the specific wording of a message. Let’s take a look at numerous ways in which two versions of something can objectively say the same thing, yet we respond in...
8.0K
01:30Frames
846
Frames are essential components of various mechanical and structural systems used daily. These structures are known for their stability and ability to bear heavy loads. A frame is constructed using two-force and multi-force members, interconnected using pin joints. In contrast, trusses are made entirely of two-force members.
Frames are versatile and widely used in various applications such as structural supports for beams and columns, automobile chassis construction, and in the construction...
Frames are versatile and widely used in various applications such as structural supports for beams and columns, automobile chassis construction, and in the construction...
846
01:26Frames: Problem Solving II
504
Consider a hydraulic hoist supporting a load of 1 kN. Assuming a simplified schematic representation of this frame structure, the force acting on BD and BF members can be determined.
504
01:24Frames: Problem Solving I
978
Consider a jib crane with an external load suspended from the pulley. The dimensions of the crane members are shown in the figure. A systematic analysis of the frame structure is required to determine the reaction forces at the pin joints, assuming that the pulleys are frictionless.
978
01:03Inertial Frames of Reference
8.8K
Newton’s first law is usually considered to be a statement about reference frames. It provides a method for identifying a special type of reference frame: the inertial reference frame. In principle, we can make the net force on a body zero. If its velocity relative to a given frame is constant, then that frame is said to be inertial. So, by definition, an inertial reference frame is a reference frame where Newton's first law holds valid. Newton's first law applies to objects with...
8.8K
01:27Non-inertial Frames of Reference
7.2K
A reference frame accelerating or decelerating relative to an inertial frame is a non-inertial frame. To help understand this, consider what taking off in an airplane, turning a corner in a car, riding a merry-go-round, and the circular motion of a tropical cyclone all have in common. All these systems are accelerating, decelerating, or rotating relative to the Earth; hence, they all are non-inertial frames. All these systems exhibit inertial forces, which merely seem to arise from motion,...
7.2K