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Related Concept Videos

Centrosome Duplication02:25

Centrosome Duplication

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The primary microtubule organizing center (MTOC) in animal cells is the centrosome. A centrosome has two cylindrical centrioles at its core. Each centriole consists of nine sets of three microtubules held together by proteins. The centrioles are positioned at right angles to each other and surrounded by a shapeless protein cloud called the pericentriolar matrix, or pericentriolar material (PCM).
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The seminal work of Ohno in 1970 popularized the idea of gene duplication and divergence. DNA sequence comparison studies reveal that a large portion of the genes in bacteria, archaebacteria, and eukaryotes was  generated by gene duplication and divergence, indicating its critical role in evolution.
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The process of chromosome duplication during cell division requires genome-wide disruption and re-assembly of chromatin. The chromatin structure must be accurately inherited, reassembled, and maintained in the daughter cells to ensure lineage propagation.
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DNA isolation protocols can be fast and straightforward or complex and time-consuming depending on the type and quality of DNA required for further processing. For example, plasmid DNA extraction is a bit more complicated than genomic DNA extraction because of the need for an appropriate lysis method to separate plasmid DNA from gDNA during isolation. However, for specific applications, such as long-range DNA sequencing that require a good yield of high- quality DNA samples, we need to follow...
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Related Experiment Video

Updated: Feb 5, 2026

Enzymatic Isolation of Skeletal Muscle Interstitial Extracellular Vesicles
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A NEW ISOLATED 20q INTERSTITIAL DUPLICATION CASE AND ITS CLINICAL COMPARISON WITH SIMILAR ISOLATED CASES.

A H Cebi, G Karaguzel, M Karakus

    Genetic Counseling (Geneva, Switzerland)
    |September 12, 2018
    PubMed
    Summary

    This study details a rare 20q duplication in a 15-year-old boy, revealing phenotypic similarities with other patients sharing the same chromosomal region. Further research may uncover links to glaucoma and Graves disease.

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    Area of Science:

    • Genetics
    • Human Chromosomes
    • Rare Diseases

    Background:

    • Chromosome 20q duplications are uncommon genetic alterations.
    • Understanding these duplications is crucial for diagnosing and managing associated health conditions.

    Observation:

    • A 15-year-old male presented with a de novo 17.1 Mb duplication on chromosome 20q.
    • Phenotypic analysis revealed similarities among patients with identical affected chromosomal regions.

    Findings:

    • Consistent phenotypic features were observed in individuals with shared 20q duplication sites.
    • Clinical follow-up data was collected for the reported patient.

    Implications:

    • The specific chromosomal region involved in 20q duplications may be associated with an increased risk of developing glaucoma and Graves disease later in life.
    • Further investigation into the genetic basis of these conditions is warranted.