Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Solution Concentration and Dilution02:59

Solution Concentration and Dilution

134.5K
The relative amount of a given solution component is known as its concentration. Often, though not always, a solution contains one component with a concentration that is significantly greater than that of all other components. This component is called the solvent and may be viewed as the medium in which the other components are dispersed or dissolved. Solutions in which water is the solvent are, of course, very common on our planet. A solution in which water is the solvent is called an aqueous...
134.5K
pH Scale02:41

pH Scale

80.0K
Hydronium and hydroxide ions are present both in pure water and in all aqueous solutions, and their concentrations are inversely proportional as determined by the ion product of water (Kw). The concentrations of these ions in a solution are often critical determinants of the solution’s properties and the chemical behaviors of its other solutes. Two different solutions can differ in their hydronium or hydroxide ion concentrations by a million, billion, or even trillion times. A common means of...
80.0K
Formation of Dilute Urine01:20

Formation of Dilute Urine

3.3K
The formation of dilute urine is a critical renal adaptation that maintains fluid balance, particularly during periods of high fluid intake. This process primarily involves the juxtamedullary nephrons. By adjusting the permeability of water and ions in response to physiological conditions, the kidneys can either conserve or excrete water, resulting in concentrated or dilute urine.
Filtrate Osmolarity in the PCT
Initially, as the filtrate passes through the proximal convoluted tubule (PCT), its...
3.3K
Scaling01:26

Scaling

596
In designing and analyzing filters, resonant circuits, or circuit analysis at large, working with standard element values like 1 ohm, 1 henry, or 1 farad can be convenient before scaling these values to more realistic figures. This approach is widely utilized by not employing realistic element values in numerous examples and problems; it simplifies mastering circuit analysis through convenient component values. The complexity of calculations is thereby reduced, with the understanding that...
596
Embryonic Stem Cells00:58

Embryonic Stem Cells

32.5K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
32.5K
Embryonic Stem Cells00:57

Embryonic Stem Cells

5.1K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
5.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A role for the <i>Stentor</i> syntaxin protein in post-wound cell survival.

Molecular biology of the cell·2026
Same author

Editorial for special issue "When should mathematical models be used in biology".

Seminars in cell & developmental biology·2026
Same author

Genome-wide analysis of mRNA regionalization in a giant single cell.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

A centrin-Sfi1 myoneme fishnet powers ultrafast calcium-triggered contraction in the giant ciliate <i>Spirostomum ambiguum</i>.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Size-dependent nucleus-vacuole interactions in budding yeast demonstrate a role for steric packing in organelle shape and positioning.

bioRxiv : the preprint server for biology·2026
Same author

Molecular pathways for learning in the single-cell Stentor coeruleus.

Current biology : CB·2026

Related Experiment Video

Updated: Feb 5, 2026

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis
10:00

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Published on: January 12, 2015

15.2K

A Dilution Model for Embryonic Scaling.

Wallace F Marshall1

  • 1Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA, USA.

Developmental Cell
|September 12, 2018
PubMed
Summary

Tissue scaling in zebrafish is achieved by a fixed amount of the Nodal inhibitor Lefty. This creates a longer gradient in larger embryos, ensuring proportional germ layer development regardless of size.

Area of Science:

  • Developmental biology
  • Embryogenesis
  • Cell signaling

Background:

  • Tissue scaling is crucial for proper embryonic development.
  • Understanding the molecular mechanisms that regulate embryo size and tissue proportion is essential.

Purpose of the Study:

  • To elucidate the mechanism by which zebrafish embryos achieve proportional tissue scaling.
  • To investigate the role of the Nodal signaling pathway in regulating embryonic size.

Main Methods:

  • Utilized zebrafish (Danio rerio) as a model organism.
  • Investigated the distribution and function of the Nodal inhibitor Lefty.
  • Analyzed gene expression patterns related to germ layer formation.

Main Results:

More Related Videos

A System for ex vivo Culturing of Embryonic Pancreas
10:51

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

14.3K
Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling
06:31

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

7.3K

Related Experiment Videos

Last Updated: Feb 5, 2026

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis
10:00

Large-scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis

Published on: January 12, 2015

15.2K
A System for ex vivo Culturing of Embryonic Pancreas
10:51

A System for ex vivo Culturing of Embryonic Pancreas

Published on: August 27, 2012

14.3K
Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling
06:31

Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling

Published on: May 3, 2019

7.3K
  • A fixed relative concentration of the diffusible Nodal inhibitor Lefty was observed.
  • Lefty produced an extended gradient in larger zebrafish embryos.
  • This mechanism ensures proportionally scaled germ layers irrespective of embryo size.

Conclusions:

  • The study reveals a novel mechanism for tissue scaling in embryonic development.
  • Lefty's concentration-dependent gradient is key to maintaining proportional germ layers during zebrafish embryogenesis.