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Updated: Feb 5, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
Published on: October 31, 2025
Mitochondrial dsRNA: A New DAMP for MDA5
Andreas Linder1, Veit Hornung2
1Gene Center and Department of Biochemistry, Ludwig-Maximilians-Universität München, Munich 81377, Germany; Department of Medicine II, University Hospital, Ludwig-Maximilians-Universität München, Munich 81377, Germany.
Abstract:
The role of mitochondria as a signaling platform downstream of the RNA sensors RIG-I and MDA5 is well defined. Now, a recent study in Nature by Dhir et al. (2018) identifies mitochondrial dsRNA as an immunogenic ligand, adding another intriguing aspect to the role of mitochondria in innate immunity.
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