The mouse as a model for neuropsychiatric drug development
James R Howe1, Mark F Bear2, Peyman Golshani3
1Departments of Neurobiology, Psychiatry & Biobehavioral Sciences and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Current address: Neurosciences Graduate Program, Department of Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.
Current Biology : CB
|September 12, 2018
Summary
Mice are valid preclinical models for brain disorders, as most treatments effective in humans also work in mice. Neurobiological differences between species are unlikely the primary reason for failed clinical translation in neuropsychiatry.
Area of Science:
- Neuroscience
- Translational Medicine
- Psychiatry
Background:
- The validity of mouse models in preclinical research for brain disorders is debated.
- High failure rates in clinical trials for neuropsychiatric conditions raise questions about species-specific neurobiology.
Purpose of the Study:
- To evaluate whether neurobiological differences between mice and humans explain the failure of translating preclinical findings into clinical success.
- To determine the primary causes of translational failures in neuropsychiatry.
Main Methods:
- Literature analysis of preclinical studies and clinical trial outcomes.
- Comparison of treatment efficacy in mouse models versus human patients for neuropsychiatric disorders.
Main Results:
- Most neuropsychiatric treatments effective in humans show at least partial efficacy in mouse models.
- Complex issues at various translation stages, beyond neurobiology, contribute to failure rates.
Conclusions:
- Neurobiological differences are unlikely the main driver of translational failures in neuropsychiatry.
- Mouse models remain valuable tools for preclinical research in brain disorders, despite translation challenges.
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