Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

16.8K
Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
16.8K
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

2.9K
Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order...
2.9K
Complex Numbers01:29

Complex Numbers

317
The real number system cannot represent the square root of a negative number, which restricts solutions for certain equations, such as quadratics with negative discriminants. To address this, the complex number system was developed, introducing the imaginary unit i, where i = √(-1). This extension allows for the representation of all roots, including those involving negative radicands.A complex number is written in the form x + yi, where x and y are real numbers. Here, x represents the...
317
Formation of Complex Ions03:45

Formation of Complex Ions

26.2K
A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.2K
Complex Power01:14

Complex Power

924
Power engineers have introduced the concept of complex power to determine the cumulative effect of parallel loads. This idea plays a crucial role in power analysis because it encompasses all the details related to the power consumed by a specific load.
Complex power is defined as the multiplication of the voltage and the complex conjugate of the current. The magnitude of this power, known as apparent power, is measured in volt-amperes (VA). Notably, the angle of the complex power equates to the...
924
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

855
In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
855

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structural basis of Fumosorinone-mediated allosteric inhibition of PTP1B for cancer immunotherapy.

Communications biology·2026
Same author

Characterization of UDP-Sugar 3-Dehydrase KsgR in the Biosynthesis of a Distinctive Multideoxy Diamino-Sugar Kasugamine of Kasugamycin.

Journal of the American Chemical Society·2026
Same author

The SWR1 complex prevents the vacuolar delivery of ATG proteins through a noncanonical pathway.

The Journal of cell biology·2026
Same author

Characterization of the SHP2-Fumosorinone interaction using biochemical and computational approaches.

Biochemical and biophysical research communications·2026
Same author

Discovery of a small-molecule inhibitor targeting human GMP synthetase.

Molecular diversity·2025
Same author

ATTEC-mediated degradation of BCR-ABL in chronic myeloid leukemia cells.

European journal of medicinal chemistry·2025

Related Experiment Video

Updated: Feb 5, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.8K

The exocyst complex.

Kunrong Mei1, Wei Guo1

  • 1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Current Biology : CB
|September 12, 2018
PubMed
Summary

The exocyst complex, conserved across eukaryotes, tethers secretory vesicles to cell membranes for fusion. This Primer details its structure, function, and roles in vital cellular processes like growth and migration.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The exocyst is a conserved, multisubunit protein complex found in eukaryotes.
  • It plays a critical role in tethering secretory vesicles to the plasma membrane.
  • This process is essential for membrane fusion mediated by SNAREs.

Purpose of the Study:

  • To provide a foundational overview of the exocyst complex.
  • To elucidate the exocyst's structure, assembly, and molecular interactions.
  • To summarize its diverse functions in cellular processes.

Main Methods:

  • Literature review and synthesis of existing research.
  • Focus on established knowledge regarding exocyst structure and function.
  • Compilation of data on exocyst's involvement in physiological processes.

More Related Videos

Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.6K
Identification of Post-translational Modifications of Plant Protein Complexes
10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

24.6K

Related Experiment Videos

Last Updated: Feb 5, 2026

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

1.8K
Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

Published on: March 2, 2020

11.6K
Identification of Post-translational Modifications of Plant Protein Complexes
10:07

Identification of Post-translational Modifications of Plant Protein Complexes

Published on: February 22, 2014

24.6K

Main Results:

  • The exocyst complex is composed of multiple subunits.
  • It facilitates vesicle tethering, a prerequisite for SNARE-mediated fusion.
  • The exocyst is implicated in exocytosis, cell growth, cytokinesis, migration, ciliogenesis, and tumorigenesis.

Conclusions:

  • The exocyst is a fundamental component of the exocytic machinery.
  • Its conserved nature highlights its importance across eukaryotic organisms.
  • Understanding the exocyst is key to comprehending various essential cellular functions and disease processes.