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Updated: Feb 5, 2026

Purification of Fibroblasts and Schwann Cells from Sensory and Motor Nerves in Vitro
Published on: May 20, 2020
Sensory and descending motor circuitry during development and injury
Giles W Plant1, Jarret Ap Weinrich2, Julia A Kaltschmidt1
1Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Abstract:
Proprioceptive sensory input and descending supraspinal projections are two major inputs that feed into and influence spinal circuitry and locomotor behaviors. Here we review their influence on each other during development and after spinal cord injury. We highlight developmental mechanisms of circuit formation as they relate to the sensory-motor circuit and its reciprocal interactions with local spinal interneurons, as well as competitive interactions between proprioceptive and descending supraspinal inputs in the setting of spinal cord injury.
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