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Low Interleukin 10 Production at Birth Is a Risk Factor for Atopic Dermatitis in Neonates with Bifidobacterium

Shuichi Suzuki1,2, Eduardo Campos-Alberto3, Yoshinori Morita3

  • 1Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japanseeyou@msj.biglobe.ne.jp.

International Archives of Allergy and Immunology
|September 12, 2018
PubMed

Insights

Infants with lower interleukin-10 (IL-10) at birth show higher atopic dermatitis (AD) risk. Early gut bacteria colonization doesn't fully offset this risk, suggesting impaired IL-10 response is key.

Area of Science:

  • Immunology
  • Microbiology
  • Pediatrics

Background:

  • Early life immune dysregulation and gut microbiota alterations are implicated in allergic disease development, such as atopic dermatitis (AD).
  • Simultaneous investigation of neonatal immune responses to microbes and gut bacterial colonization is limited.

Purpose of the Study:

  • To analyze neonatal immune responses to microbial stimuli and beneficial gut bacteria colonization.
  • To determine the relationship between these factors and the development of AD in a birth cohort.

Main Methods:

  • Recruited pregnant women and followed infants until 7 months.
  • Measured interleukin-10 (IL-10) from cord blood mononuclear cells (CBMCs) stimulated with specific bacteria and bacterial components.
  • Quantified fecal Bifidobacterium counts and assessed AD development via questionnaire.

Main Results:

  • Infants who developed AD exhibited significantly lower IL-10 levels in response to all microbial stimuli compared to healthy infants.
  • In infants with Bifidobacterium colonization, higher IL-10 release was inversely associated with AD incidence.

Conclusions:

  • Impaired IL-10 production in neonates may increase the risk of developing infantile atopic dermatitis.
  • This risk persists even in the presence of early intestinal Bifidobacterium colonization.
Abstract

Keywords:
Atopic dermatitisBifidobacteriumCord bloodInnate immunityInterleukin 10Intestinal microbiotaNeonateRisk factor

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