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Related Concept Videos

Genomics02:02

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Issues And Trends In Healthcare Delivery System01:29

Issues And Trends In Healthcare Delivery System

The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
Cost Containment
Payment for healthcare services has historically promoted adoption of costly and often unnecessary or inefficient...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

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Related Experiment Video

Updated: Jun 21, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Sepsis: Personalized Medicine Utilizing 'Omic' Technologies-A Paradigm Shift?

Theis Skovsgaard Itenov1, Daniel D Murray2, Jens Ulrik Stæhr Jensen3,4

  • 1PERSIMUNE, Rigshospitalet, Copenhagen DK-2100, Denmark. theis.skovsgaard.itenov@regionh.dk.

Healthcare (Basel, Switzerland)
|September 13, 2018
PubMed
Summary

Sepsis treatment is challenging due to patient heterogeneity. Advanced

Keywords:
genomicsmetabolomicssepsissystems biologytranscriptomicstransitional research

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Related Experiment Videos

Last Updated: Jun 21, 2026

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
13:24

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies

Published on: April 11, 2016

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments
07:46

Microfluidic Co-Culture Models for Dissecting the Immune Response in in vitro Tumor Microenvironments

Published on: April 30, 2021

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Area of Science:

  • Critical care medicine
  • Genomics
  • Biochemistry

Background:

  • Sepsis remains a significant clinical challenge with high mortality.
  • Traditional treatments have failed to improve sepsis prognosis due to population heterogeneity.
  • Personalized medicine offers a potential solution by targeting specific patient mechanisms.

Purpose of the Study:

  • To review the potential of 'omics' technologies in understanding sepsis.
  • To discuss the application of personalized medicine in sepsis treatment.
  • To explore the challenges and opportunities in applying advanced technologies to sepsis.

Main Methods:

  • Review of current literature on sepsis and 'omics' technologies.
  • Analysis of the heterogeneity of sepsis patient populations.
  • Discussion of genetic and biochemical characterization methods.

Main Results:

  • 'Omics' technologies enable detailed patient characterization.
  • Personalized treatment strategies can be developed based on individual patient profiles.
  • Understanding specific pathophysiological mechanisms is key to effective treatment.

Conclusions:

  • Advanced 'omics' technologies are crucial for a paradigm shift in sepsis management.
  • Personalized treatment approaches hold promise for improving sepsis outcomes.
  • Further research is needed to overcome the pitfalls of implementing these advanced technologies.