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The bark of Passiflora edulis (BPe) effectively improved body composition and metabolic health in obese mice. It reduced body fat, cholesterol, and triglycerides while enhancing antioxidant capacity and lowering oxidative stress markers.

Keywords:
Passiflora edulisdb/db miceobesityoxidative stress

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Area of Science:

  • Biochemistry
  • Pharmacology
  • Nutrition Science

Background:

  • Obesity is a significant risk factor for chronic diseases like diabetes, hypertension, and atherosclerosis, often linked to inflammation and oxidative stress.
  • Passiflora edulis is rich in bioactive compounds including phenolics, carotenoids, vitamin C, and polyamines.

Purpose of the Study:

  • To investigate the effects of Passiflora edulis bark (BPe) on body composition, metabolic profiles, and oxidative stress in genetically obese mice.

Main Methods:

  • Obese male db/db mice were fed standard chow for 8 weeks, then divided into two groups for 8 more weeks: standard chow or standard chow with BPe.
  • Evaluated parameters included food/caloric intake, body weight, body fat, plasma glucose, triglycerides, total cholesterol, malondialdehyde (MDA), and antioxidant capacity.

Main Results:

  • BPe significantly reduced visceral and subcutaneous fat, adiposity index, cholesterol, and triglyceride levels.
  • Treatment with BPe improved plasma antioxidant capacity and decreased malondialdehyde (MDA) levels, indicating reduced oxidative stress.

Conclusions:

  • The bark of Passiflora edulis demonstrated efficacy in improving body composition and metabolic health in obese mice.
  • BPe positively influenced antioxidant status and reduced markers of oxidative stress, suggesting therapeutic potential for obesity-related metabolic dysfunction.