Related Experiment Video
Updated: Feb 5, 2026
11:51
Combining Behavioral Endocrinology and Experimental Economics: Testosterone and Social Decision Making
Published on: March 2, 2011
15.7K
Testosterone replacement therapy and hospitalization rates in men with COPD
Jacques Baillargeon1,2, Randall James Urban3, Wei Zhang3
11 Department of Preventive Medicine and Community Health, University of Texas Medical Branch, Galveston, TX, USA.
Chronic Respiratory Disease
|September 13, 2018
Summary
Testosterone replacement therapy (TRT) may reduce respiratory hospitalizations in men with chronic obstructive pulmonary disease (COPD). This study found TRT users experienced a greater decrease in hospitalizations compared to non-users.
Area of Science:
- Pulmonary Medicine
- Endocrinology
Background:
- Testosterone deficiency is prevalent in men with chronic obstructive pulmonary disease (COPD) and may worsen their condition.
- Previous research indicates testosterone replacement therapy (TRT) might improve respiratory health in men with COPD, but large-scale studies are lacking.
Purpose of the Study:
- To investigate if TRT reduces the risk of respiratory hospitalizations in middle-aged and older men diagnosed with COPD.
Main Methods:
- Two retrospective cohort studies were conducted using large US databases (Clinformatics Data Mart and Medicare).
- Difference-in-differences (DID) statistical modeling compared pre- and post-treatment hospitalization rates for TRT users versus matched non-users.
Main Results:
- TRT users showed a significantly greater relative decrease in respiratory hospitalizations compared to non-users.
- Middle-aged TRT users experienced a 4.2% greater decrease (p=0.03), and older TRT users had a 9.1% greater decrease (p=0.04).
Conclusions:
- TRT may potentially slow disease progression in men with COPD.
- Further research in larger cohorts is warranted to explore the biological mechanisms behind this association.
Related Concept Videos
01:30Continuous Renal Replacement Therapy
1.1K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.1K
00:59Hospitals-II
1.2K
Hospitals provide inpatient and outpatient services. Inpatient services provide care to patients that stay in the hospital for an extended period, ranging from days to months. Examples of inpatient services include intensive care units, hospital wards, or surgeries. Outpatient services provide care to patients who come to a hospital for a diagnostic or treatment but do not stay overnight —for example, diagnostic tests, surgical procedures, or health education.
Nurses that work in...
Nurses that work in...
1.2K
01:28Hospitals-I
1.7K
Hospitals offer medical and surgical care to the sick and injured, along with accommodation while they recover. At the same time, they also provide outpatient, emergency, psychiatric, and rehabilitation services to meet various community needs. In addition to providing medical care, hospitals also act as hubs for medical research and training. Hospitals use clinical procedures and evidence-based practice standards to deliver patient care. To deliver safe and efficient care, a nurse must stay up...
1.7K
01:26Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy
224
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
224
01:26Testosterone: Functions and Regulation
2.3K
The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
2.3K
01:20COPD: Pathogenesis and Clinical Features
1.9K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K