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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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Subatomic Particles03:37

Subatomic Particles

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Dalton was only partially correct about the particles that make up matter. All matter is composed of atoms, and atoms are composed of three smaller subatomic particles: protons, neutrons, and electrons. These three particles account for the mass and the charge of an atom.
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C4 Pathway and CAM01:27

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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The Nucleosome Core Particle02:10

The Nucleosome Core Particle

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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The Nucleosome Core Particle01:12

The Nucleosome Core Particle

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Nucleosomes are the DNA-histone complex, where the DNA strand is wound around the histone core. The histone core is an octamer containing two copies of H2A, H2B, H3, and H4 histone proteins.
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Related Experiment Video

Updated: Feb 5, 2026

Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages
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Quantification of Monocyte Chemotactic Activity In Vivo and Characterization of Blood Monocyte Derived Macrophages

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Modified LDL Particles Activate Inflammatory Pathways in Monocyte-derived Macrophages: Transcriptome Analysis.

Alexander N Orekhov1,2, Yumiko Oishi3, Nikita G Nikiforov1,4

  • 1Laboratory of Angiopathology, Institute of General Pathology and Pathophysiology, 125315 Moscow, Russian Federation.

Current Pharmaceutical Design
|September 13, 2018
PubMed
Summary
This summary is machine-generated.

Modified LDL triggers inflammation as the primary immune cell response. Cholesterol metabolism changes appear secondary to inflammatory signaling in atherosclerosis development.

Keywords:
AtherosclerosisLDLinflammationmacrophagesmodified LDLpro-inflammatory signaling.

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Visualization of Inflammatory Caspases Induced Proximity in Human Monocyte-Derived Macrophages
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Area of Science:

  • Immunology
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Atherosclerosis pathogenesis involves complex interactions between cholesterol metabolism and inflammation.
  • Myeloid cells, particularly macrophages, play a critical role by accumulating cholesterol and becoming foam cells.
  • The relationship between inflammatory responses and cholesterol metabolism in macrophages during atherogenesis remains unclear.

Purpose of the Study:

  • To identify key regulator genes in macrophages responding to modified low-density lipoprotein (LDL).
  • To elucidate the interplay between inflammation and cholesterol metabolism pathways in atherosclerosis.

Main Methods:

  • Utilized a bioinformatics approach to analyze gene expression in macrophages treated with atherogenic modified LDL.
  • Focused on identifying master regulator genes involved in the cellular response.

Main Results:

  • Identified numerous genes primarily involved in inflammatory pathways.
  • Notably, no identified key genes were directly implicated in cholesterol metabolism.
  • Key inflammatory genes identified include Interleukin (IL)-7, IL-7 receptor, IL-15, and CXCL8.

Conclusions:

  • The primary immune cell response to modified LDL is the activation of inflammatory pathways.
  • Alterations in lipid metabolism genes are likely a secondary consequence of inflammatory signaling.
  • This suggests inflammation drives early cellular changes in atherosclerosis before significant lipid accumulation effects are regulated.