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The Dual Specificity Role of Transcription Factor FOXO in Type 2-diabetes and Cancer

Kaneez Fatima1, Shilu Mathew2, Muhammed Faheem3

  • 1Department of Applied Biochemistry, Faculty of Sciences, University of Jeddah 23445, Jeddah, Saudi Arabia.

Current Pharmaceutical Design
|September 13, 2018
PubMed

Insights

Forkhead box O (FOXO) transcription factors regulate vital cellular processes, including cancer development. Understanding FOXO biology offers potential for novel cancer therapeutics.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • FOXO transcription factors are crucial regulators of cellular processes like proliferation, apoptosis, metabolism, and cancer.
  • Four FOXO family members in humans share structural and functional similarities.
  • Specific FOXO members, like FOXO1 and FOXO3, have distinct tissue expression patterns and roles.

Purpose of the Study:

  • To provide a comprehensive overview of FOXO protein biology.
  • To explore the therapeutic potential of targeting FOXO pathways in cancer treatment.

Main Methods:

  • This review synthesizes existing literature on FOXO transcription factors.
  • Key signaling pathways and interactions involving FOXO proteins are discussed.

Main Results:

  • FOXO proteins are involved in diverse cellular functions, including response to reactive oxygen species (ROS), cell cycle regulation, and programmed cell death.
  • FOXO3 acts as a tumor suppressor, interacting with p53 and regulating apoptosis and stem cell renewal.
  • FOXO1 plays a role in metabolic regulation, particularly in adipose tissue.

Conclusions:

  • FOXO proteins are central to various physiological processes and disease states, notably cancer.
  • Targeting FOXO pathways presents a promising avenue for developing innovative cancer therapies.
Keywords:
Forkhead box Ocancercell proliferationpolymorphismtherapeutictranscription factors.

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