Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer02:18

Cancer

54.4K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
54.4K
What is Cancer?02:12

What is Cancer?

14.4K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
14.4K
Cancer Prevention02:59

Cancer Prevention

8.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
8.1K
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Cancer Vaccines01:30

Cancer Vaccines

1.1K
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
1.1K
Skin Cancer01:30

Skin Cancer

5.9K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
5.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From the Vitamin D Paradox to Precision Nutrition: Targeted Supplementation, Assay Pitfalls, and Clinical Decision-Making.

Current nutrition reports·2026
Same author

Revisiting the Lipid-Cancer Axis: PCSK9, ANGPTL3, and CETP as Emerging Biomarkers and Therapeutic Targets in Oncology.

Biomolecules·2026
Same author

Hormonal, metabolic and metabolomic biomarkers in long COVID.

Advances in clinical chemistry·2026
Same author

Ultra-Processed Foods and Chronic Kidney Disease: Is Inflammaging the Missing Link?

Biomolecules·2026
Same author

Unravelling Sarcopenia in Chronic Kidney Disease: From Pathogenesis to Diagnosis and Therapeutics.

Diagnostics (Basel, Switzerland)·2026
Same author

Vitamin D and Health Outcomes: State-of-the-Art Review of Triangulated Evidence and Ongoing Controversies.

Current nutrition reports·2026

Related Experiment Video

Updated: Feb 5, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K

Silimarin and Cancer.

Christina Liakopoulou1, Christos Kazazis1, Natalia G Vallianou1

  • 1Evangelismos General Hospital, 45-47 Ipsilantou Str, 10676, Athens, Greece.

Anti-Cancer Agents in Medicinal Chemistry
|September 13, 2018
PubMed
Summary

Silymarin, a natural compound, inhibits cancer cell proliferation and induces apoptosis through ER stress. Research is exploring its potential as an adjuvant therapy, particularly in non-small cell lung cancer (NSCLC).

Keywords:
EMT regulatorsPD-L1Silimarinanti-angiogenic propertiesapoptosisbioavailabilityinhibit cell proliferationsilibin.

More Related Videos

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K

Related Experiment Videos

Last Updated: Feb 5, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

18.9K
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
09:45

Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines

Published on: August 21, 2019

7.5K
Isolation of Cancer Stem Cells From Human Prostate Cancer Samples
07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K

Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Oncology

Background:

  • Silymarin is a natural extract rich in silibinin A and B.
  • It is derived from plant sources using ethanol, methanol, and acetone extraction.

Purpose of the Study:

  • To investigate the anti-cancer properties of silymarin.
  • To explore its potential as an adjuvant therapy in cancer treatment, particularly NSCLC.

Main Methods:

  • Studies demonstrate silymarin's ability to inhibit cell proliferation and induce apoptosis.
  • The induction of apoptosis is linked to endoplasmic reticulum (ER) stress pathways.

Main Results:

  • Silibinin acts as a STAT3 inhibitor and downregulates PD-L1 and EMT regulators.
  • It suppresses cancer cells by targeting actin cytoskeleton and PI3K/Akt pathways.
  • Silibinin interacts with the p53 tumor suppressor gene.

Conclusions:

  • Silymarin shows promise as an adjuvant in non-small cell lung cancer (NSCLC) therapy.
  • Enhancing silymarin's bioavailability through nanoformulations is under investigation for future clinical use with chemotherapy.