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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation

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An overview of current and emerging devices for percutaneous left atrial appendage closure

Danny H F Chow1, Yam-Hong Wong2, Jai-Wun Park3

  • 1The Heart Center, Rigshospitalet, Copenhagen, Denmark.

Trends in Cardiovascular Medicine
|September 13, 2018
PubMed

Insights

Atrial fibrillation (AF) patients can prevent stroke with left atrial appendage (LAA) closure devices. This review covers current and emerging LAA occluders, focusing on design and clinical data for stroke risk reduction.

Area of Science:

  • Cardiology
  • Medical Devices
  • Stroke Prevention

Background:

  • Atrial fibrillation (AF) is a major risk factor for ischemic stroke.
  • Oral anticoagulant (OAC) therapy is standard for stroke prevention but has bleeding risks and tolerability issues.
  • Left atrial appendage (LAA) closure provides a non-pharmacological alternative for stroke prevention in AF patients.

Purpose of the Study:

  • To provide an overview of current and emerging left atrial appendage (LAA) occluder devices.
  • To highlight key design features of various LAA occluders.
  • To summarize available preclinical and clinical data for LAA closure devices.

Main Methods:

  • Literature review of current and emerging LAA occluder devices.
  • Analysis of device design features.
  • Synthesis of preclinical and clinical data.

Main Results:

  • Several LAA occluder devices are available, with distinct design characteristics.
  • Emerging devices offer potential improvements in safety and efficacy.
  • Clinical data demonstrate the feasibility and effectiveness of LAA closure for stroke prevention.

Conclusions:

  • LAA closure is a viable non-pharmacological strategy for stroke prevention in non-valvular AF.
  • Device design and clinical data are crucial for selecting appropriate LAA occluders.
  • Continued research and development in LAA occluder technology are ongoing.

Keywords:
Atrial fibrillationLeft atrial appendage closureStroke preventionTranscatheter

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