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Bin Zhu1,2, Juan Wang3, Lingling Qin4

  • 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.

Bioscience Reports
|September 13, 2018
PubMed
Summary

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This summary is machine-generated.

The fibroblast growth factor receptor 2 gene (FGFR2) rs2981582 polymorphism, specifically the AA genotype, is linked to a higher risk of developing non-functioning pituitary adenoma (NFPA). This genetic association was confirmed across different inheritance models.

Area of Science:

  • Genetics
  • Endocrinology
  • Oncology

Background:

  • The fibroblast growth factor receptor 2 (FGFR2) gene polymorphism rs2981582 is a known risk factor for breast cancer.
  • Its potential role in non-functioning pituitary adenoma (NFPA) remains unexplored.

Purpose of the Study:

  • To investigate the association between the FGFR2 rs2981582 polymorphism and the risk of developing NFPA.
  • To determine if specific genotypes of rs2981582 influence NFPA susceptibility.

Main Methods:

  • A case-control study involving 79 NFPA patients and 142 healthy controls.
  • DNA extraction from peripheral blood samples.
  • Genotyping of the rs2981582 polymorphism using the MassARRAY method.

Main Results:

Keywords:
FGFR2GenotypeNon-functioning pituitary adenomaPolymorphism

Related Experiment Videos

  • The AA genotype of FGFR2 rs2981582 was significantly associated with an increased risk of NFPA (OR = 1.743, P=0.008).
  • This association remained significant after adjusting for risk factors (OR = 1.862, P=0.008).
  • Recessive (OR = 3.051, P=0.005) and additive models (AG: OR = 0.329, P=0.009; AA: OR = 0.326, P=0.009) also indicated an increased risk of NFPA.

Conclusions:

  • The FGFR2 rs2981582 AA genotype is associated with a higher risk of non-functioning pituitary adenoma.
  • Genetic variations in FGFR2 may play a role in the pathogenesis of NFPA.