Research integrity and the law that never was

Evidence-based medicine is arguably among the most important innovations of the modern era, but publication bias and inadequate research transparency are serious issues affecting the very foundation of evidence-based practice. Despite this truth, these crucial issues have gone largely unaddressed or inadequately addressed for a distressingly long period of time. Regulatory efforts have thus far proven insufficient in eliminating these issues. Fortunately, the last 5 years in particular have seen developments that one hopes will contribute to the eradication of these issues and a future where we can look back on these issues as a sordid story of our past. However, much like the purported fixes of the past, time will be the final arbiter of the efficacy of remedial measures currently underway. This article chronicles the history of these issues, failed attempts to fix these issues, and what can be and is being done with the hope of bringing about true resolution.