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Related Experiment Video

Updated: Feb 5, 2026

Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions

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Published on: November 30, 2022

Copper-boryl mediated organic synthesis.

David Hemming¹, Russell Fritzemeier, Stephen A Westcott

¹Department of Chemistry, University of Durham, Science Laboratories South Road, Durham DH1 3LE, UK. p.g.steel@durham.ac.uk.

Chemical Society Reviews

|September 13, 2018

Summary

This summary is machine-generated.

Copper-boryl reagents offer a versatile and cost-effective method for synthesizing organoboron compounds. This review explores copper-boryl chemistry, highlighting its utility in various bond-forming reactions.

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Area of Science:

Organic Chemistry
Synthetic Chemistry

Background:

Organoboron compounds are crucial synthetic intermediates.
Boronate esters are highly versatile boron derivatives.
Efficient methods for generating boronate esters are of significant interest.

Purpose of the Study:

To review methodologies in copper-boryl chemistry.
To survey the diverse transformations enabled by copper-boryl reagents.

Main Methods:

Discussion of various copper-boryl reagent methodologies.
Survey of different chemical transformations.

Main Results:

Copper-boryl reagents enable mild reaction conditions.
These reagents exhibit good functional group tolerance.
The use of inexpensive copper catalysts is highlighted.

Conclusions:

Copper-boryl chemistry provides an attractive approach for organoboron compound synthesis.
This methodology facilitates diverse C-X and C-C bond-forming reactions.