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TRPV1 and BDKRB2 receptor polymorphisms can influence the exercise pressor reflex
Karambir Notay1, Shannon L Klingel1, Jordan B Lee1
1Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
The Journal of Physiology
|September 13, 2018
Summary
Genetic variations in skeletal muscle receptors TRPV1 and BDKRB2 influence blood pressure responses during exercise, particularly in men. These findings suggest a potential risk factor for exaggerated exercise blood pressure.
Area of Science:
- Exercise physiology
- Human genetics
- Cardiovascular research
Background:
- Inter-individual variability in blood pressure (BP) response to exercise is significant.
- Mechanisms underlying this variability, especially related to skeletal muscle afferent feedback, are not fully understood.
- Previous research focused on sympathetic outflow genes, neglecting skeletal muscle metaboreceptors.
Purpose of the Study:
- To investigate the association between single-nucleotide polymorphisms (SNPs) in skeletal muscle metaboreceptor genes and exercise-induced BP responses.
- To determine if genetic variants in TRPV1, ASIC3, BDKRB2, PTGER2, and P2RX4 influence BP and heart rate during static handgrip exercise and mental stress.
Main Methods:
- 200 healthy men and women underwent measurements of continuous BP and heart rate during static handgrip exercise, post-exercise occlusion, and mental stress.
- Participants were genotyped for specific SNPs in TRPV1 (rs222747), ASIC3 (rs2288645), BDKRB2 (rs1799722), PTGER2 (rs17197), and P2RX4 (rs25644).
Main Results:
- Lower exercise systolic BP was observed in GG carriers of TRPV1 rs222747 compared to minor allele carriers.
- Lower exercise diastolic BP and heart rate were found in CC carriers of BDKRB2 rs1799722 compared to minor allele carriers.
- Individuals with minor alleles in both TRPV1 rs222747 and BDKRB2 rs1799722 exhibited greater BP responses during exercise, with a more pronounced effect in men. No associations were found for other SNPs or during mental stress.
Conclusions:
- Genetic variants in TRPV1 and BDKRB2 skeletal muscle receptors contribute to inter-individual differences in exercise BP responses.
- The effects of these genetic variants are additive and more pronounced in men.
- Skeletal muscle metaboreceptor genetic variations may represent a risk factor for exaggerated blood pressure responses during exercise.
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