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Vaccines in pediatric transplant recipients-Past, present, and future

Daniel E Dulek1, Annabelle de St Maurice2, Natasha B Halasa1

  • 1Division of Pediatric Infectious Diseases, Department of Pediatrics, Vanderbilt University Medical Center, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.

Pediatric Transplantation
|September 13, 2018
PubMed

Insights

Vaccine-preventable diseases pose risks for children after transplantation. This review examines evidence for pediatric immunizations, focusing on child-specific studies to improve transplant outcomes.

Area of Science:

  • Pediatric transplantation
  • Immunology
  • Infectious diseases

Background:

  • Infections are a major concern for pediatric transplant recipients.
  • Vaccine-preventable diseases increase morbidity and mortality post-transplant.
  • Existing immunization guidelines often lack pediatric-specific data.

Purpose of the Study:

  • To review the evidence for selected immunizations in pediatric transplant recipients.
  • To identify gaps in knowledge and areas for future research.
  • To emphasize studies focusing exclusively on pediatric populations.

Main Methods:

  • Literature review of published studies.
  • Focus on studies involving pediatric solid organ and hematopoietic stem cell transplant recipients.
  • Prioritization of studies with pediatric-only cohorts.

Main Results:

  • Evidence for many pediatric immunizations is limited.
  • Recommendations are often extrapolated from adult or mixed-age studies.
  • Further pediatric-specific research is needed to refine guidelines.

Conclusions:

  • Optimizing immunization strategies is crucial for pediatric transplant success.
  • Pediatric-specific research is essential for evidence-based guidelines.
  • Addressing vaccine-preventable diseases improves long-term transplant outcomes.

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