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Alarming and Threatening Signals from Health Centers About Multi Drug Resistance Staphylococcus haemolyticus

Abbas Maleki1, Sobhan Ghafourian1,2, Morovat Taherikalani3

  • 1Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.

Infectious Disorders Drug Targets
|September 13, 2018
PubMed
Abstract

Insights

Antibiotic resistance is increasing in Staphylococcus haemolyticus, a common cause of infections. This study found a link between the IS 256 gene and weak biofilm formation in methicillin-resistant S. haemolyticus, highlighting a public health concern.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Coagulase-negative staphylococci (CoNS) contribute to antibiotic resistance and virulence through biofilm formation.
  • Staphylococcus haemolyticus exhibits significant diversity and increasing antibiotic resistance, necessitating detailed investigation.

Purpose of the Study:

  • To analyze phenotypic and genotypic biofilm formation in Staphylococcus haemolyticus.
  • To determine antibiotic resistance patterns and identify associated genes.
  • To perform SCCmec and ACME typing on methicillin-resistant S. haemolyticus (MRSH) isolates.

Main Methods:

  • Collected 256 CoNS isolates, with 49 identified as S. haemolyticus.
  • Evaluated antibiotic resistance using disk agar diffusion.
  • Performed biofilm assays and SCCmec/ACME typing on MRSH isolates.

Main Results:

  • High resistance rates observed for cotrimoxazole and erythromycin (86.6%).
  • Prevalence of blaA (96.5%) and msrA (79.3%) genes was high; IS 256 was the most frequent biofilm-correlated gene (79.31%).
  • 58.6% of MRSH isolates showed weak biofilm formation, and SCCmec type V was dominant.

Conclusions:

  • A correlation exists between the IS 256 gene and weak biofilm phenotype in MRSH isolates.
  • Multiple antibiotic resistances in S. haemolyticus pose a significant public health warning.
Keywords:
CoNSMRSHSCCmec typingStaphylococcus haemolyticusantibiotic resistancebiofim.

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