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Trapping of Micro Particles in Nanoplasmonic Optical Lattice
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Multilayered Nanoplasmonic Arrays for Self-Referenced Biosensing.

Justin R Sperling1, Gerard Macias1, Steven L Neale1

  • 1Biomedical Engineering Research Division, School of Engineering , University of Glasgow , Glasgow G128LT , U.K.

ACS Applied Materials & Interfaces
|September 13, 2018
PubMed
Summary

This study introduces a novel multilayered localized surface plasmon resonance (LSPR) sensor. The design integrates sensing and reference layers to self-correct for environmental drift, improving accuracy in chemical and biological detection.

Keywords:
LSPRbiosensormultilayerplasmonicsself-referencing

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Area of Science:

  • Nanotechnology
  • Optical Sensing
  • Biomedical Engineering

Background:

  • Localized surface plasmon resonance (LSPR) nanosensors offer sensitive, label-free detection.
  • Extreme sensitivity to refractive index changes makes them prone to environmental drift (temperature, light).
  • Existing drift correction methods require dual channels, increasing device size and complexity.

Purpose of the Study:

  • To develop a novel multilayered LSPR sensor design.
  • To integrate both sensing and reference layers within a single region.
  • To enable self-correction for sensor drift without a secondary reference channel.

Main Methods:

  • Design and fabrication of a multilayered LSPR sensor.
  • Incorporation of an encapsulated reference layer alongside the sensing layer.
  • Demonstration using sucrose concentration measurements and biotin-avidin interaction detection.

Main Results:

  • The multilayered sensor successfully monitored and corrected for sensor drift.
  • Accurate measurements of sucrose concentration were achieved.
  • Specific molecular interactions (biotin-avidin) were detected with self-corrected drift.

Conclusions:

  • The integrated multilayered LSPR sensor design effectively compensates for environmental drift.
  • This approach eliminates the need for a separate reference channel, simplifying devices.
  • The sensor shows significant promise for miniaturized, point-of-care diagnostic applications.