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Updated: Feb 5, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Enzalutamide after chemotherapy in advanced castration-resistant prostate cancer: the Italian Named Patient Program
Francesca Maines1, Ugo De Giorgi2, Giuseppe Procopio3
1Medical Oncology, S Chiara Hospital, Largo Medaglie d'Oro 1, Trento, Italy.
Aim:
To collect efficacy and safety data of enzalutamide after docetaxel, we retrospectively evaluated the Italian Named Patient Program results.
Patients & Methods:
Two hundred and nine metastatic castration-resistant prostate cancer patients were enrolled. Median age was 73 years. Total 42.1% patients had pain, 14.4% had a performance status of two and 59.8% had a Gleason score ≥8. Total 31.1% had previously received ≥2 chemotherapies, 15.3 and 12% had been previously treated with abiraterone and cabazitaxel, respectively and 14.8% had received both.
Results:
Median progression-free survival and overall survival were 4.8 and 13.1 months, respectively. A prostate-specific antigen reduction ≥50% was observed in 49.1%. Total 32.7% abiraterone-pretreated patients achieved a biochemical response compared with 56% of abiraterone-naive patients.
Conclusion:
Enzalutamide was safe and well tolerated. Its antitumor activity in abiraterone-pretreated patients was limited.
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