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The Assessment of Serum Endocan Levels in Children With Juvenile Idiopathic Arthritis
Yasin Yilmaz1, Rana Berru Durmuş1, Başak Saraçoğlu1
1Department of Pediatrics, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.
Insights
Serum endocan levels are elevated in children with juvenile idiopathic arthritis (JIA), suggesting endothelial damage. No significant difference was found between active and inactive JIA cases.
Area of Science:
- Pediatric Rheumatology
- Biomarkers
- Endothelial Function
Background:
- Juvenile idiopathic arthritis (JIA) is a chronic autoimmune disease affecting children.
- Endothelial dysfunction is increasingly recognized in chronic inflammatory conditions.
Purpose of the Study:
- To investigate serum endocan levels in pediatric patients diagnosed with JIA.
- To explore the relationship between serum endocan and disease activity in JIA.
Main Methods:
- A cohort of 67 children with JIA and 39 healthy controls were recruited.
- Serum endocan levels were measured and compared between groups.
- JIA patients were stratified into active and inactive disease subgroups.
Main Results:
- Serum endocan levels were significantly higher in children with JIA compared to healthy controls (p<0.01).
- No significant difference in serum endocan levels was observed between active and inactive JIA groups (p=0.34).
- A weak negative correlation was noted between Childhood Health Assessment Questionnaire scores and serum endocan levels.
Conclusions:
- Elevated serum endocan in JIA patients indicates potential endothelial damage.
- Serum endocan may serve as a biomarker for endothelial involvement in pediatric arthritis.
Objectives:
This study aims to evaluate the levels of serum endocan in children with juvenile idiopathic arthritis (JIA).
Patients And Methods:
Sixty-seven children with JIA (30 males, 37 females; mean age 10.4±4.9 years; range 2 to 18 years) and a sex- and age- matched healthy control group of 39 children (16 males, 23 females; mean age 9.3±4.1 years; range 1 to 17 years) were recruited. Patients with JIA were divided into two groups as the clinically active JIA group (n=27) and inactive JIA group (n=40).
Results:
The median serum endocan level in patients with JIA was significantly higher than in the control group (633.75 ng/L vs. 379.76 ng/L, p<0.01). Comparison between patients with active JIA and inactive JIA was not significant in terms of endocan levels (618.70 ng/L vs. 687.36 ng/L, p=0.34). There was a weak negative correlation between Childhood Health Assessment Questionnaire scores of patients with JIA and serum endocan levels.
Conclusion:
The high level of serum endocan highlighted the endothelial damage in patients with JIA.
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