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Honeycomb-Satellite Structured pH/H

Qianqian Sun1, Fei He1, Chunqiang Sun1

  • 1Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Material Sciences and Chemical Engineering , Harbin Engineering University , Harbin 150001 , P. R. China.

ACS Applied Materials & Interfaces
|September 13, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a novel nanoplatform for photodynamic therapy (PDT) that responds to tumor microenvironment conditions. This smart system enhances PDT efficacy by generating reactive oxygen species (ROS) and enabling multimodal bioimaging.

Keywords:
ROSbioimaginghoneycomb MnO2photodynamic therapyupconversion

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Solid tumors present an oxygen-deprived environment, limiting photodynamic therapy (PDT) effectiveness.
  • Developing advanced nanoplatforms is crucial for overcoming these therapeutic challenges.

Purpose of the Study:

  • To engineer a smart, pH-controllable, and H2O2-responsive nanoplatform for enhanced PDT.
  • To create a degradable nanoplatform capable of delivering photosensitizers and acting as a multimodal bioimaging agent.

Main Methods:

  • Fabrication of honeycomb manganese oxide (hMnO2) nanospheres loaded with Ce6-sensitized up-conversion nanoparticles (UCNPs).
  • Utilized H2O2 and acidic conditions for controlled release of UCNPs.
  • Investigated the generation of reactive oxygen species (ROS) upon 808 nm laser irradiation.
  • Evaluated multimodal bioimaging capabilities including upconversion luminescence (UCL), MRI, and CT imaging.

Main Results:

  • The developed nanoplatform (hMUC) demonstrated pH-controllable and H2O2-responsive degradation, releasing loaded UCNPs.
  • Efficient generation of cytotoxic ROS was achieved, indicating potential for PDT.
  • The hMUC nanoplatform exhibited excellent performance as a contrast agent for UCL, MRI, and CT imaging.
  • In vitro and in vivo experiments confirmed the potential of hMUC for imaging-guided tumor diagnosis and treatment.

Conclusions:

  • The hMUC nanoplatform offers a promising strategy for overcoming the limitations of PDT in hypoxic tumor environments.
  • Its multimodal bioimaging capabilities support imaging-guided diagnosis and treatment, paving the way for advanced cancer therapy.