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Can Plasma Rich in Growth Factors Be Safe for Parental Use? A Safety Study in the Canine Model
Elena Damiá1, Deborah Chicharro2, Mónica Rubio3,4
1Bioregenerative Medicine and Applied Surgery Research Group, Department of Animal Medicine and Surgery, Faculty of Veterinary, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Valencia, Spain. elena.damia@uchceu.es.
Abstract:
Low invasiveness is the main goal of modern surgery. The use of platelet-rich plasma (PRP) is known to be effective in a variety of applications, such as oral, maxillofacial, orthopedic, dermatologic and cosmetic surgeries. However, a potential ergogenic and carcinogenic effect of PRP derivatives by means of the insulin-like growth factor-1 (IGF-1) pathway has been suggested. Because of this notion, the purpose of this study is to assess the effect of a commercially available PRP-derivative intramuscular injection in the lumbar muscular tissue (local effect) and to determine the IGF-1 blood concentration (systemic effect) on healthy beagle dogs. Local effect was evaluated by computed tomography (CT) scan and echography, and systemic effect was calculated by blood testing on days 0, 14, 28, 42 and 56. No statistically significant changes were observed; thus, PRGF could be considered safe when using therapeutic doses.
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This style is strict and controlling, with little room for open dialogue. Authoritarian parents demand obedience and often enforce rules with minimal warmth. Children raised this way may lack social skills and initiative, usually comparing themselves to others unfavorably.
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