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Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors

Peter L Stavinoha1, Martha A Askins2, Stephanie K Powell3

  • 1The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. pstavinoha@mdanderson.org.

Bioengineering (Basel, Switzerland)
|September 14, 2018
PubMed

Insights

Pediatric brain tumor (PBT) survivors often experience long-term neurocognitive and psychosocial challenges impacting quality of life. Further research is crucial for developing effective interventions to improve outcomes for these survivors.

Area of Science:

  • Neuroscience
  • Psychology
  • Oncology

Background:

  • Late neurocognitive and psychosocial effects of pediatric brain tumor (PBT) treatment are significant clinical concerns.
  • These effects negatively impact survivors' quality of life, education, and employment.
  • Multiple factors influence these outcomes, including tumor characteristics, treatment, individual factors, and support systems.

Purpose of the Study:

  • To review existing research on late effects in PBT survivors.
  • To highlight the need for innovative research to improve neurocognitive and psychosocial outcomes.

Main Methods:

  • Literature review of studies on pediatric brain tumor late effects.
  • Analysis of factors contributing to neurocognitive and psychosocial outcomes.
  • Brief description of current intervention paradigms.

Main Results:

  • Declines in intelligence are common and persistent.
  • Core deficits in attention, processing speed, and working memory are prevalent.
  • Psychological issues include depression, anxiety, and adjustment difficulties.

Conclusions:

  • Understanding PBT late effects requires ongoing research.
  • Innovative interventions are needed to enhance neurocognitive and psychosocial outcomes for PBT survivors.
  • Early-stage research on interventions necessitates further development.

Keywords:
cognitivelate effectsneurocognitivepediatric brain tumorpsychosocialsurvivorship

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