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Obstructive Ileocolitis in Patients With Obstructed Colorectal Cancer - A Matched Case Control Study
Ning-Qi Pang1, Tian-Zhi Lim1, Yuanpei Zhou1
1Division of Colorectal Surgery, University Surgical Cluster, National University Health System, Singapore.
Annals of Coloproctology
|September 14, 2018
Summary
Obstructive ileocolitis in colorectal cancer patients presents with metabolic acidosis and elevated lactate. Early identification of these biochemical markers is crucial for predicting this severe condition.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Obstructive ileocolitis is an inflammatory condition linked to colorectal cancer.
- It can lead to serious complications like intestinal perforation if untreated.
Purpose of the Study:
- To identify predictive factors for obstructive ileocolitis in patients with colorectal cancer.
- To differentiate patients with obstructive ileocolitis from those with obstructive colorectal cancer alone.
Main Methods:
- A retrospective case-control study was conducted.
- 21 patients with obstructive ileocolitis and colorectal cancer were matched with 21 controls with obstructive colorectal cancer but without ileocolitis.
- Data on demographics, clinical presentation, tumor characteristics, and laboratory values were analyzed.
Main Results:
- Patients with obstructive ileocolitis showed significantly higher total leucocyte count and serum lactate levels.
- They also presented with lower pCO2, HCO3, and base excess, indicating metabolic acidosis with respiratory compensation.
- No significant differences were found in comorbidities, clinical symptoms, or tumor characteristics. Radiological features were not predictive.
Conclusions:
- Obstructive ileocolitis is associated with specific biochemical markers: metabolic acidosis, raised lactate, and leukocytosis.
- Radiological findings are not useful for predicting obstructive ileocolitis.
- These biochemical indicators may aid in early diagnosis and management.
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