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Priapism induced by various psychotropics: A case series
Timo Greiner1, Michael Schneider1, Johannes Regente1,2
1University Clinic for Psychiatry and Psychotherapy, Brandenburg Medical School , Rüdersdorf , Germany.
Summary
Priapism, a prolonged erection, is a rare side effect of psychotropic medications. This study highlights drug initiation, dosage changes, and SSRI interactions as key risk factors for developing this condition.
Area of Science:
- Psychiatry
- Pharmacology
- Urology
Background:
- Priapism is a known, albeit rare, adverse effect associated with various psychotropic medications.
- Both typical and atypical antipsychotics, along with trazodone, have been implicated in causing priapism.
- The exact mechanism remains unclear, but is hypothesized to involve the alpha-adrenergic blocking effects of these drugs.
Purpose of the Study:
- To investigate the association between psychotropic drug use and priapism.
- To identify potential risk factors and patterns related to psychotropic-induced priapism.
Main Methods:
- Analysis of 19 cases of priapism from the AMSP database.
- Review of existing case reports to identify similarities and risk factors.
Main Results:
- Common patterns included immediate priapism onset after initiating a specific psychotropic drug.
- Changes in drug plasma concentration, due to dosage adjustments or co-medication with certain SSRIs, were also associated with priapism.
- Priapism can occur across a wide range of ages and dosages.
Conclusions:
- Clinicians should maintain a high index of suspicion for priapism in patients using psychotropic medications.
- Early recognition and reporting of symptoms like prolonged erections are crucial for timely intervention.
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