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Predictive value of fasting blood glucose for serious coronary atherosclerosis in non-diabetic patients

Tong Zhao1, Hui-Ping Gong1, Zhao-Qiang Dong1

  • 1Department of Cardiology, the Second Hospital of Shandong University, Shandong University, Ji-nan, Shandong Province, China.

The Journal of International Medical Research
|September 14, 2018
PubMed

Insights

High fasting blood glucose (FBG) predicts severe coronary artery disease (CAD) in non-diabetic individuals. Early intervention for hyperglycemia in non-diabetics with chest discomfort is recommended.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Coronary artery disease (CAD) poses a significant health burden.
  • The role of hyperglycemia in CAD severity is under investigation, particularly in non-diabetic individuals.

Purpose of the Study:

  • To investigate if high fasting blood glucose (FBG) is an independent predictor of serious coronary lesions in patients with CAD.

Main Methods:

  • 64 patients with chest discomfort underwent coronary angiography.
  • Fasting blood glucose (FBG) levels were measured.
  • Coronary artery lesion severity was assessed using the Gensini score.

Main Results:

  • Both diabetes and FBG showed a significant positive correlation with the Gensini score.
  • Diabetes was an independent predictor of Gensini score >41, but FBG was not.
  • In non-diabetic patients, FBG was significantly associated with a Gensini score >41.

Conclusions:

  • Hyperglycemia, indicated by elevated FBG, independently predicts severe coronary artery disease (CAD) in non-diabetic patients.
  • Clinicians should consider FBG levels in non-diabetic patients presenting with symptoms suggestive of CAD.
  • Early intervention for elevated FBG in non-diabetic individuals may help mitigate CAD severity.
Abstract

Keywords:
Fasting blood glucoseGensini scorecoronary artery diseasediabetes mellitushyperglycemiaprediction

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