Big Data Cohort Extraction to Facilitate Machine Learning to Improve Statin Treatment
Chih-Lin Chi1,2, Jin Wang1,2, Thomas R Clancy1,2
11 University of Minnesota, Minneapolis, MN, USA.
Western Journal of Nursing Research
|September 14, 2018
Summary
Domain experts are crucial for selecting patient data cohorts in Big Data studies. This ensures machine learning models effectively support clinical practice, like preventing statin adverse events.
Area of Science:
- Health Informatics
- Machine Learning Applications
Background:
- Big Data in healthcare offers potential for clinical practice improvement.
- Machine learning (ML) is a key analytic tool for data-driven decision support across industries.
Purpose of the Study:
- To highlight the critical role of domain experts in Big Data analysis.
- To demonstrate a method for extracting a relevant patient cohort for ML model development.
Main Methods:
- Utilized Big Data from the OptumLabs™ Data Warehouse (130 million de-identified lives).
- Employed domain expertise to define criteria for patient data cohort selection.
- Extracted a specific patient cohort of 37,506 individuals for ML analysis.
Main Results:
- Feature-selection tools alone are insufficient for creating effective patient data cohorts.
- Domain expert input is essential for maximizing the success of ML projects in healthcare.
Conclusions:
- Domain experts are vital for identifying valuable data elements and defining patient cohorts in Big Data studies.
- This process is key to developing successful machine learning strategies for clinical practice improvement.
More Related Videos
Related Concept Videos
01:19Facilitated Transport
149.0K
The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
149.0K
01:19Facilitated Transport
18.8K
The chemical and physical properties of plasma membranes cause them to be selectively permeable. Since plasma membranes have both hydrophobic and hydrophilic regions, substances need to be able to transverse both regions. The hydrophobic area of membranes repels substances such as charged ions. Therefore, such substances need special membrane proteins to cross a membrane successfully. In facilitated transport, also known as facilitated diffusion, molecules and ions travel across a...
18.8K
01:04Social Facilitation
36.6K
Not all intergroup interactions lead to negative outcomes. Sometimes, being in a group situation can improve performance. Social facilitation occurs when an individual performs better when an audience is watching than when the individual performs the behavior alone. This typically occurs when people are performing a task for which they are skilled.
36.6K
01:16Facilitated Diffusion
1.3K
The plasma membrane, a critical structure in cellular biology, houses an array of transporters, or carrier proteins, interspersed within its lipid bilayer. These proteins play a crucial role in solute transport through facilitated diffusion, a form of passive diffusion that uses transporters to move the molecules across the membrane.
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
In this process, substrates such as organic compounds and ions interact with a transporter on one side, triggering conformational changes in proteins that enable...
1.3K
01:19Machines
579
Machines are complex structures consisting of movable, pin-connected multi-force members that work together to transmit forces. One example of a machine is the cutting plier, which is used to cut wires by applying forces to its handles. When equal and opposite forces are exerted on the handles of the cutting plier, they cause the cutting edges to come together and apply equal and opposite reaction forces on the wire, which are greater than the applied forces.
A free-body diagram of the...
A free-body diagram of the...
579
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.4K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.4K