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Updated: Feb 5, 2026

Fabrication of 1-D Photonic Crystal Cavity on a Nanofiber Using Femtosecond Laser-induced Ablation
Published on: February 25, 2017
Fabrication of Zn-Sr-doped laser-spinning glass nanofibers with antibacterial properties
María Magdalena Echezarreta-López1, Trinidad de Miguel1,2, Félix Quintero3
11 Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Campus Vida, Universidad Santiago de Compostela, Santiago de Compostela 15782, Spain.
Abstract:
The morphology and dimensions of bioactive materials are essential attributes to promote tissue culture. Bioactive materials with nanofibrous structure have excellent potential to be used as bone-defect fillers, since they mimic the collagen in the extracellular matrix. On the other hand, bioactive glasses with applications in regenerative medicine may present antibacterial properties, which depend on glass composition, concentration and the microorganisms tested. Likewise, their morphology may influence their antibacterial activity too. In the present work, the laser-spinning technique was used to produce bioactive glass nanofibers of two different compositions: 45S5 Bioglass® and ICIE16M, bioactive glass doped with zinc and strontium. Their antibacterial activity against Staphylococcus aureus was tested by culturing them in dynamic conditions. Bacterial growth index profiles during the first days of experiment can be explained by the variations in the pH values of the media. The bactericidal effect of the doped nanofibers at longer times is justified by the release of zinc and strontium ions. Cytotoxicity was analyzed by means of cell viability tests performed with BALB/3T3 cell line.
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