Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stereoisomerism of Cyclic Compounds02:33

Stereoisomerism of Cyclic Compounds

11.1K
In this lesson, we delve into the role of ring conformation and its stability, which determines the spatial arrangement and, consequently, the molecular symmetry and stereoisomerism of cyclic compounds. 1,2-Dimethylcyclohexane is used as a case study to evaluate the possible number of stereoisomers. Here, given the multiple (n = 2) chiral centers, there are 2n = 4 possible configurations that lack a plane of symmetry, as the ring skeleton exists in a non-planar chair conformation. In addition,...
11.1K
Voltammetric Techniques: Cyclic Voltammetry01:10

Voltammetric Techniques: Cyclic Voltammetry

1.6K
Cyclic voltammetry (CV) is an electrochemical technique used to investigate the redox properties of a chemical species. It involves measuring the current response of an electrochemical cell as a function of the applied potential. The setup for cyclic voltammetry typically consists of a working electrode, a reference electrode, and a counter electrode—all immersed in an electrolyte solution. The working electrode is where the redox reaction of interest occurs, while the reference electrode...
1.6K
Cyclic Processes And Isolated Systems01:19

Cyclic Processes And Isolated Systems

3.5K
A thermodynamic system with zero heat exchange and work is an isolated system. For these systems, the internal energy remains constant.
In the case of a non-isolated system, the change in the internal energy is zero only if the process is cyclic. A thermodynamic process is considered cyclic if the system undergoes a series of changes and returns to its initial state. 
Consider a cyclic process that returns to its initial state, undergoing a four-step process. The heat transfer along each...
3.5K
Behavior of Concrete Under Compressive Load01:23

Behavior of Concrete Under Compressive Load

639
Concrete exhibits specific behaviors under different compressive loads. Understanding this is crucial for understanding its structural integrity. When concrete undergoes uniaxial compression, it tends to develop cracks that run parallel to the direction of the force. These parallel cracks stem from localized tensile stresses that occur perpendicular to the compression direction. Additionally, angled cracks may appear due to the formation of shear planes.
As the concrete specimen fractures under...
639
Relation Between Tensile Strength and Compressive Strength of Concrete01:30

Relation Between Tensile Strength and Compressive Strength of Concrete

685
Concrete is a fundamental building material, and understanding its strengths is crucial for construction projects. The relationship between its tensile and compressive strengths is intricate, showing that while these strengths are related, they do not increase at the same rate. Tensile strength's growth is slower and is affected by various factors such as the methods used for testing, the size and shape of the specimen, the texture of the aggregate used, and the moisture content of the...
685
Local Attraction01:22

Local Attraction

387
Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
387

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Voluntary wheel running attenuates peptidoglycan-polysaccharide-induced inflammation and preserves skeletal muscle remodeling in male C57BL/6J mice.

Physiological reports·2026
Same author

Biochemical state in tissue can be detected through ultrasound signal.

npj biomedical innovations·2026
Same author

Baseline characteristics, perioperative complications, and 1-year outcomes in cervical OPLL versus cervical spondylotic myelopathy: a multicenter retrospective cohort study.

North American Spine Society journal·2026
Same author

Pain and paresthesia patterns in degenerative cervical myelopathy: neuropathic sensory features and postoperative transitions in a prospective cohort.

The spine journal : official journal of the North American Spine Society·2026
Same author

Bone mineral density in pediatric Marfan syndrome patients with scoliosis: a retrospective case-control study using hounsfield units.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Lumbar degenerative surgery in dialysis-dependent patients: complications and patient-reported outcomes.

The spine journal : official journal of the North American Spine Society·2026

Related Experiment Video

Updated: Feb 5, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

8.7K

Local cyclical compression modulates macrophage function

Kumiko Saitou1,2, Masakuni Tokunaga1, Daisuke Yoshino3

  • 1Department of Rehabilitation for Motor Functions, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama 359-8555, Japan.

Clinical Science (London, England : 1979)
|September 14, 2018
PubMed
Summary

Mechanical interventions like massage can combat muscle atrophy caused by inactivity. Local cyclical compression (LCC) reduces inflammation and restores muscle function by modulating macrophage activity, offering a new therapeutic approach.

Keywords:
disuse muscle atrophyfluid shear stressinterstitial fluidmacrophagemassagephysical inactivity

More Related Videos

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.7K
Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity
08:52

Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity

Published on: March 30, 2018

9.3K

Related Experiment Videos

Last Updated: Feb 5, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity

Published on: June 7, 2017

8.7K
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
07:47

Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function

Published on: February 4, 2016

13.7K
Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity
08:52

Neuron-Macrophage Co-cultures to Activate Macrophages Secreting Molecular Factors with Neurite Outgrowth Activity

Published on: March 30, 2018

9.3K

Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Physiology

Background:

  • Physical inactivity leads to diseases and aging-related dysfunctions, including muscle atrophy.
  • Sedentary lifestyles exacerbate locomotive issues and can disrupt vital organs.
  • Molecular mechanisms underlying physical activity's benefits remain unclear.

Purpose of the Study:

  • To investigate the molecular mechanisms by which mechanical interventions alleviate muscle atrophy.
  • To explore the role of macrophages in immobilization-induced muscle atrophy and inflammation.
  • To determine if mechanical stimulation can modulate macrophage function and mitigate muscle loss.

Main Methods:

  • Local cyclical compression (LCC) applied to mouse calf muscles.
  • Hindlimb immobilization to induce muscle atrophy.
  • Depletion of circulating macrophages using clodronate liposomes.
  • In vitro experiments applying pulsatile fluid shear stress and hydrostatic pressure to macrophages.

Main Results:

  • LCC partially restored myofiber thickness and muscle contracting forces.
  • LCC reduced pro-inflammatory markers (TNF-α, MCP-1) and macrophage infiltration.
  • Macrophage depletion negated the beneficial effects of LCC on muscle atrophy.
  • Pulsatile fluid shear stress, not hydrostatic pressure, reduced MCP-1 expression in macrophages.

Conclusions:

  • Mechanical interventions, specifically LCC, can alleviate immobilization-induced muscle atrophy.
  • Macrophage mechanosensory function plays a critical role in disuse muscle atrophy.
  • Mechanical modulation of macrophages presents a novel therapeutic strategy for muscle atrophy.