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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
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Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films
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Periodontal cell mechanotransduction.

Sasanka S Chukkapalli1,2, Tanmay P Lele3

  • 1Department of Oral Biology, University of Florida, College of Dentistry, Gainesville, FL 32610, USA.

Open Biology
|September 14, 2018
PubMed
Summary

Mechanical forces significantly impact periodontal cells, influencing their function in both health and disease. Understanding these cellular mechanisms is crucial for addressing periodontal conditions.

Keywords:
cell shapecytoskeletonmechanobiologymechanotransductionperiodontal diseasetraction force

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Area of Science:

  • Biomaterials Science
  • Cell Biology
  • Dental Research

Background:

  • The periodontium anchors teeth and comprises diverse cell types like stem cells, fibroblasts, and epithelial cells.
  • Periodontal cells are continuously subjected to mechanical stresses from mastication, tongue movements, and implants.

Purpose of the Study:

  • To review the existing literature on the effects of mechanical forces on periodontal cells.
  • To emphasize the molecular and cellular mechanisms involved in these responses in both health and disease.

Main Methods:

  • Literature review of studies investigating mechanical forces on periodontal cells.
  • Analysis of molecular and cellular mechanisms underlying cellular responses to mechanical stress.

Main Results:

  • Mechanical stresses modulate the function of various periodontal cell types.
  • These forces play a significant role in the pathogenesis of periodontal disease.

Conclusions:

  • Mechanical forces are critical regulators of periodontal cell behavior.
  • Further research into these mechanisms can inform therapeutic strategies for periodontal diseases.