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Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
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Antifungal Resistance in Dermatology
Varadraj Pai1, Ajantha Ganavalli2, Naveen Narayanshetty Kikkeri3
1Department of Dermatology, Goa Medical College, Bambolim, Goa, India.
Indian Journal of Dermatology
|September 14, 2018
Summary
Antifungal drug resistance is a growing problem in treating fungal infections. Combinational antifungal therapy offers a promising strategy to overcome resistance and improve treatment outcomes.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pharmacology
Background:
- Cutaneous fungal infections are highly prevalent, affecting over 25% of the global population.
- Fungal infection severity is influenced by both host immunity and non-immunological factors.
- Widespread antifungal drug use, especially in immunocompromised patients, has led to significant antifungal resistance.
Purpose of the Study:
- To explore the multifaceted nature of antifungal drug resistance.
- To discuss the contributing factors to both microbiological and clinical resistance.
- To highlight combinational antifungal therapy as a strategy to combat resistance.
Main Methods:
- Review of existing literature on fungal pathogenesis and drug resistance mechanisms.
- Analysis of factors contributing to microbiological (fungal genetic alterations) and clinical (host/drug) resistance.
- Evaluation of combinational antifungal therapy's potential benefits.
Main Results:
- Antifungal resistance can arise from fungal genetic changes or host/drug-related issues, acting alone or together.
- Combinational antifungal therapy can enhance synergistic action and broaden the spectrum of activity.
- Understanding resistance mechanisms is key to developing effective therapies.
Conclusions:
- Antifungal resistance is a complex issue driven by microbial and clinical factors.
- Combinational antifungal therapy presents a viable strategy to improve efficacy and overcome resistance.
- Further research into resistance mechanisms is crucial for advancing antifungal treatment.
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