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Updated: Feb 5, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Treatment of horizontal defect with and without platelet-rich fibrin matrix: A randomized comparative clinical study
Koel Debnath1, Anirban Chatterjee1
1Department of Periodontology, The Oxford Dental College, Bengaluru, Karnataka, India.
Aim:
The aim of the present study was to assess the clinical and radiographical parameters in horizontal bone defects in patients with chronic periodontitis.
Materials And Methods:
In this randomized, controlled clinical trial study, nine individuals with 94 sites having moderate to deep periodontitis were selected and distributed to Group A - open flap debridement (OFD), Group B - open flap debridement and intra marrow penetration (OFD + IMP) and Group C - Open flap debridement + Intramarrow penetration + platelet rich fibrin matrix (OFD + IMP + PRFM). Plaque index (PI) and gingival index (GI) were evaluated at baseline, 6 months, and 9 months after surgery. Probing pocket depth (PPD) and clinical attachment level (CAL) were recorded at baseline and 9 months after surgery. Radiographic assessment was carried out to measure the periodontal defect depth and defect fill percentage (DF%) at baseline and 9 months after the surgery using radiovisiography.
Results:
The statistical evaluation obtained after 9 months showed no significant difference between PI and GI at 9 months interval. Intergroup comparison of PPD and CAL has shown significant difference in Group C as compared to Group A and B with P < 0.05. The defect depth was statistically significant at 9 months in all the groups, and DF percentage (DF%) has shown statistically significant results in Group C as compared to A and B with P = of 0.001.
Conclusion:
The addition of PRFM to horizontal type of periodontal defects has shown promising results over a 9-month follow-up period.
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