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Related Concept Videos

Review and Preview01:10

Review and Preview

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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
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Review and Preview01:13

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Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
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Rous Sarcoma Virus (RSV) and Cancer01:03

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Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
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What are Cells?01:07

What are Cells?

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Cells are the smallest and basic units of life, whether it is a single cell that forms the entire organism, e.g., in a bacterium or trillions of them, e.g., in humans. No matter what organism a cell is a part of, they share specific characteristics.
Basic Characteristics of Cells
A living cell has a plasma membrane, a bilayer of lipids that separates the aqueous solution inside the cell called the cytoplasm from the outside environment.
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Chemistry of the Cell02:58

Chemistry of the Cell

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The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
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Updated: Feb 5, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
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Clear cell sarcoma-A review.

Rami Mossad Ibrahim1, Signe Steenstrup Jensen2, Jacob Juel3

  • 1Department Plastic and Reconstructive Surgery, Herlev Hospital, Copenhagen, Denmark.

Journal of Orthopaedics
|September 14, 2018
PubMed
Summary
This summary is machine-generated.

Clear cell sarcoma (CCS), a rare soft tissue malignancy, is distinct from malignant melanoma (MM). Early diagnosis and surgical treatment are crucial for improving the poor survival rates associated with CCS in young adults.

Keywords:
Clear cell sarcomaMalignant melanoma of the soft tissueSarcomaTreatment of clear cell sarcoma

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Area of Science:

  • Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Clear cell sarcoma (CCS) was formerly misdiagnosed as malignant melanoma (MM) of soft tissue.
  • Advanced histopathologic and cytogenetic methods now allow clear differentiation between CCS and MM.
  • CCS is a rare soft tissue sarcoma, accounting for approximately 1% of all sarcomas.

Purpose of the Study:

  • To provide a comprehensive overview of clear cell sarcoma.
  • To highlight the diagnostic challenges and advancements in distinguishing CCS from MM.
  • To emphasize the importance of early detection and treatment for this rare cancer.

Main Methods:

  • Review of current histopathologic and cytogenetic diagnostic techniques.
  • Analysis of epidemiological data regarding age of diagnosis and survival rates.
  • Synthesis of information on treatment strategies, focusing on radical surgery.

Main Results:

  • Clear cell sarcoma is now definitively distinguishable from malignant melanoma using modern diagnostic tools.
  • The median age of diagnosis for CCS is 25 years, predominantly affecting young adults.
  • Mortality rates for CCS are high, with a 5-year survival ranging from 40% to 60%.

Conclusions:

  • Accurate diagnosis of clear cell sarcoma is essential and achievable with contemporary techniques.
  • Radical surgical intervention is a critical component in managing this rare and aggressive soft tissue malignancy.
  • Improved early diagnosis and treatment are vital to enhance patient outcomes for clear cell sarcoma.