Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.3K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.3K
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association between circadian rest-activity rhythm and meal timing: NHANES 2013-2014.

Sleep health·2026
Same author

Chronotype, Race, and Gender.

Journal of biological rhythms·2026
Same author

Seasonal patterns of body temperature in response to experimental photoperiod variation in a non-hibernating ground squirrel.

Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology·2023
Same author

Advancing chronobiology across the spectrum.

Chronobiology international·2021
Same author

Circadian rhythmicity of body temperature and metabolism.

Temperature (Austin, Tex.)·2020
Same author

Diverse styles of running-wheel behavior in antelope ground squirrels.

Behavioural processes·2020

Related Experiment Video

Updated: Feb 5, 2026

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings
08:20

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings

Published on: June 6, 2015

15.9K

Focal Epilepsy and the

Roberto Refinetti1

  • 1Department of Psychological Science, Boise State University, Boise, Idaho.

Pediatric Neurology Briefs
|September 14, 2018
PubMed
Summary

Researchers studied human epilepsy tissue and mouse models to investigate the role of the Clock gene in the condition. Findings reveal Clock gene

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Epilepsy is a neurological disorder characterized by recurrent seizures.
  • The circadian rhythm, regulated by the Clock gene, influences various physiological processes.
  • Dysregulation of circadian rhythms has been implicated in neurological conditions.

Purpose of the Study:

  • To investigate the role of the Clock gene in human epileptogenic tissue.
  • To explore the functional impact of Clock gene deletion in a mouse model of epilepsy.

Main Methods:

  • Transcriptome analysis of human epileptogenic tissue.
  • Generation and behavioral testing of mouse lines with targeted Clock gene deletions.

Main Results:

Keywords:
Clock-Flox Mouse LineFocal Cortical DysplasiaHuman Epileptogenic Tissue

More Related Videos

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.3K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K

Related Experiment Videos

Last Updated: Feb 5, 2026

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings
08:20

Brain Source Imaging in Preclinical Rat Models of Focal Epilepsy using High-Resolution EEG Recordings

Published on: June 6, 2015

15.9K
Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring
11:28

Robotic-Guided Stereoelectroencephalography for Invasive Epilepsy Monitoring

Published on: June 13, 2025

1.3K
A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery
09:41

A Pipeline for 3D Multimodality Image Integration and Computer-assisted Planning in Epilepsy Surgery

Published on: May 20, 2016

12.7K
  • Transcriptome analysis identified alterations in gene expression in human epilepsy tissue.
  • Mouse models with Clock gene deletions exhibited specific neurological phenotypes relevant to epilepsy.

Conclusions:

  • The Clock gene plays a significant role in the pathophysiology of epilepsy.
  • Targeting the Clock gene pathway may offer novel therapeutic strategies for epilepsy treatment.