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Updated: Feb 5, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
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Prognostic value of

Hui Wang1, Yaxing Zhou1, Qian Liu1

  • 1The Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, China, 394202231@qq.com.

Oncotargets and Therapy
|September 14, 2018
PubMed
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High SOX2 expression in esophageal squamous cell carcinoma (ESCC) indicates better survival. Conversely, high p53 and Cyclin D1 expression, along with venous invasion, predict poor prognosis and survival in ESCC patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Esophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with complex molecular underpinnings.
  • Identifying reliable prognostic and predictive biomarkers is crucial for improving patient outcomes in ESCC.

Purpose of the Study:

  • To investigate the expression of SOX2, Cyclin D1, p53, and ki-67 in ESCC tissues.
  • To correlate these protein expressions with clinicopathological features and patient survival outcomes.
  • To evaluate the prognostic significance of these markers, individually and in combination, for overall and progression-free survival in ESCC.

Main Methods:

  • Immunohistochemical analysis of SOX2, Cyclin D1, p53, and ki-67 expression in 117 surgically resected ESCC samples and adjacent normal tissues.
Keywords:
Cyclin D1SOX2esophageal squamous cell carcinomaki-67p53prognosis

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  • Correlation of protein expression levels with clinicopathological data, including lymph node metastasis, organ metastasis, tumor stage, differentiation, venous invasion, and patient survival.
  • Multivariate Cox regression analysis to identify independent predictors of prognosis.

    • Main Results:

    • High expression of SOX2, Cyclin D1, p53, and ki-67 was detected in 46.1%, 70.1%, 54.7%, and 32.5% of ESCC tissues, respectively.
    • SOX2 expression correlated significantly with N stage, differentiation, and ki-67 expression. High SOX2 expression was associated with better patient survival (p=0.021).
    • High p53 expression and Cyclin D1 expression were correlated (p=0.015). High p53 expression, venous invasion, and therapy were independent predictors of unfavorable overall survival. Co-overexpression of p53 and Cyclin D1 correlated with poor overall and progression-free survival.

    Conclusions:

    • SOX2 may serve as a potential prognostic indicator and therapeutic target in ESCC.
    • p53 expression, particularly in combination with Cyclin D1, holds significant unfavorable prognostic value in ESCC.
    • Further research into the molecular mechanisms of drug resistance in ESCC is warranted based on these findings.