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Related Experiment Video

Updated: Feb 5, 2026

Micro-drive Array for Chronic in vivo Recording: Drive Fabrication
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Neuroimmune Activation Drives Multiple Brain States.

Daria Tchessalova1, Caitlin Kelly Posillico2, Natalie Celia Tronson1,2

  • 1Neuroscience Graduate Program, School of Medicine, University of Michigan, Ann Arbor, MI, United States.

Frontiers in Systems Neuroscience
|September 14, 2018
PubMed
Summary

Neuroimmune signaling influences memory, emotion, and cognition. Illness or injury can cause lasting changes in brain function and behavior by shifting the neuroimmune baseline.

Keywords:
brain statescognitionlearning and memoryneuroimmunepersistent changesvulnerability

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Area of Science:

  • Neuroscience
  • Immunology
  • Cognitive Science

Background:

  • Neuroimmune signaling, involving microglia, astrocytes, and cytokines, is crucial for cognitive and emotional processes.
  • Research is actively exploring how these interactions modulate behavior during and after illness or injury.

Purpose of the Study:

  • To discuss neuroimmune activation as a mechanism for different behavioral states.
  • To propose a continuum of neuroimmune states from homeostatic to chronic activation.
  • To highlight the enduring impact of neuroimmune activation on neural function and behavior.

Main Methods:

  • Discussing neuroimmune activation as a mechanism.
  • Proposing a continuum of neuroimmune states.
  • Identifying states via cytokine/glial patterns, behavior, and epigenetics.

Main Results:

  • Neuroimmune activation triggers states that modulate cognition and emotion for adaptive behavior.
  • Cognitive and mood impairments can persist post-illness due to lasting shifts in the homeostatic baseline.
  • Distinct neuroimmune states can be identified multidimensionally.

Conclusions:

  • Identifying neuroimmune states offers a framework for predicting vulnerability to memory, cognition, and emotion disorders.
  • Understanding these states is key for predicting long-term consequences of illness or injury.
  • This research provides a basis for understanding persistent deficits in neural function and behavior.