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Pioglitazone, a PPAR-γ Activator, Stimulates BK

Tsang-Shan Chen1, Ming-Chi Lai2, Te-Yu Hung2

  • 1Department of Neurology, Tainan Sin-Lau Hospital, Tainan, Taiwan.

Frontiers in Pharmacology
|September 14, 2018
PubMed
Summary

Pioglitazone stimulates Ca2+-activated K+ currents and inhibits M-type K+ currents in hippocampal neurons. These effects on potassium channels may explain its broad pharmacological actions.

Keywords:
Ca2+-activated K+ currentM-type K+ currenthippocampal neuronlarge-conductance Ca2+-activated K+ channelpioglitazone

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