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In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide
Antimicrobial Agents and Chemotherapy
|August 1, 1986
Abstract:
Polymyxin B nonapeptide, prepared by enzymic removal of the fatty acyl diaminobutyric acid side chain from polymyxin B, was about 100-fold less toxic to K562 cells than polymyxin B. MICs of polymyxin B nonapeptide against a test panel of bacteria were 2- to 64-fold lower than those of polymyxin B.